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Herwig, Annika, Vries, Emmely M. de, Bolborea, Matei, Wilson, Dana, Mercer, Julian G., Ebling, Francis J. P., Morgan, Peter J. and Barrett, Perry (2013)Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the siberian hamster (Phodopus sungorus). PLoS One, 8 (4). pp. 1-10. e62003. doi:10.1371/journal.pone.0062003 ISSN 1932-6203.
Koh, Gavin C. K. W., Weehuizen, Tassili A., Breitbach, Katrin, Krause, Kathrin, Jong, Hanna K. de, Kager, Liesbeth M., Hoogendijk, Arjan J., Bast, Antje, Peacock, Sharon J., van der Poll, Tom, Steinmetz, Ivo and Wiersinga, W. Joost (2013)Glyburide reduces bacterial dissemination in a mouse model of melioidosis. PLoS Neglected Tropical Diseases, Volume 7 (Number 10). e2500. doi:10.1371/journal.pntd.0002500 ISSN 1935-2727.
Dr. Yamanaka used a retrovirus to insert four genes into a mousecell to return it to a "pluripotent" state-capable of turning intoalmost any kind of cell. Last month a team at Johns HopkinsUniversity and the Sloan-Kettering Institute for Cancer Research,using a version of Dr. Yamanaka's technique, successfully grew nerve cells from a patient suffering froma rare disease called Riley-Day syndrome, which is linked to earlymortality, seizures and other symptoms and caused by a fault in onegene.
This week's award of the Nobel Prize for medicine to John Gurdonand Shinya Yamanaka effectively recognizes the science ofepigenetics. Dr. Gurdon showed that almost any cell (in a frog)contains all the genetic information to become an adult. What makesthe cell develop a certain way is a pattern of "epigenetic"modifications to the DNA specific to each tissue-turning genes onand off. Dr. Yamanaka showed that if you can remove that epigeneticmodification (in a mouse) you can reprogram a cell to be anembryo.